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No long term clinical human studies currently exist
5,6 The approval of semaglutide was based on findings from the global phase 3 STEP (Semaglutide Treatment Effect in People with Obesity) program and the SELECT (Semaglutide Effects on Cardiovascular Outcomes in People with Overweight or Obesity) trial, which showed clinically significant body-weight reductions of 9.6 to 17.4% in persons with overweight or obesity with or without diabetes, as well as reductions in cardiometabolic risk factors and in cardiovascular events
Refrigeration is the protocol
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Animals given high doses for extended periods didn't show obvious toxicity
Localized injection near the injury site is sometimes used for tendon or joint issues
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