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In contrast, eating too close to bedtime can cause gastrointestional discomfort and suppress melatonin, as insulin and other postprandial changes can modulate melatonin release, thus impairing sleep (Zuraikat et al., 2021)

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For focal pigmented lesions, a biopsy is necessary to arrive at a definitive diagnosis

DSIP vs Epithalon: two different mechanisms, two different patients Delta Sleep-Inducing Peptide (DSIP) is a neuropeptide that acts directly on sleep centers in the brain to initiate sleep onset and increase non-REM sleep time