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B-12 shots increase metabolism

Medvidovic-Grubisic M, Stambolija V, Kolenc D, Katancic J, Murselovic T, Plestina-Borjan I, et al

Vitamin B12 shots can also be administered at home in the form of a subcutaneous injection

The Immediate Phase: First 24 to 48 Hours For patients with a significant deficiency, the first couple of days can feel like a meaningful change

While theres no definite cutoff for when B12 starts to become unsafe, because people often ask, well somewhat arbitrarily say not to take more than 1,000 g per day over the long-term without guidance from a physician