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Advances in Nutrition Research, 18(2), 145-160

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Common (typically mild and transient): Increased appetite (moderate, less than GHRP-6) Flushing and warmth at the injection site or face Transient drowsiness or sleepiness, particularly with evening doses Mild water retention and peripheral edema Increased gastrointestinal motility Less Common: Elevations in cortisol and ACTH (moderate, comparable to hCRH) Mild prolactin elevation (less than TRH-induced levels) Numbness or tingling in extremities Joint stiffness Lightheadedness post-injection Rare or Theoretical Concerns: Impaired glucose metabolism and elevated blood glucose with prolonged use Potential tachyphylaxis (reduced response) with continuous daily dosing Theoretical promotion of existing malignancies through elevated GH/IGF-1 (applies to all GH-elevating compounds) Side effect incidence tends to be lower than with exogenous hGH because GHRP-2 stimulates endogenous GH synthesis within physiological regulatory limits

36 , e22637 (2022)

Cancer Res 63(9):23222329 Huang H et al (2015) VEGF suppresses T-lymphocyte infiltration in the tumor microenvironment through inhibition of NF-kappaB-induced endothelial activation