The sustained levels may also increase the likelihood of certain side effects, particularly joint stiffness and water retention
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If your provider recommends higher doses or if you've enrolled in a multi-vial plan, each vial maintains independent stability from its own compounding date
In: Deisenhammer F, Teunissen CE, Tumani H, editors
Start your intake What the Long-Term Clinical Data Actually Shows The largest long-term semaglutide trial, SUSTAIN-5, tracked patients for 230 weeks (over 4 years) and found that gastrointestinal side effectsnausea, vomiting, constipationwere most common during dose escalation phases but declined significantly once patients stabilized on their maintenance dose