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We found that cisplatin treatment caused a decrease in mitochondrial biogenesis (PGC-1, NRF-1, TFAM, mtDNA, ND1), mitochondrial mass (Porin and Citrate synthase activity) and fusion index (MFN2, Drp1), together with changes in the expression of autophagy-related genes (AKT/FoxO pathway, Atg1, Beclin1, LC3AII, p62) and enhanced ROS production (PRX III, MnSOD)
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Huang J, Li L, Lian J, Schauer S, Vesely PW, Kratky D, et al
Thirugnanam SS, Ragunathan S (2024) Hepatoprotective potential of esculetin loaded chitosan nanoparticles (ESC-CNPs) in DMBA-induced mammary carcinogenesis in Sprague-Dawley rats
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