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The activation of ChaC1 by UPR primarily relies on ATF4, while the involvement of CHOP, C/EBP-, and ATF3 is indirect (12)
This has motivated therapeutic strategies that modulate proteostasis to recalibrate immune responses rather than solely suppress downstream inflammation
10.1104/pp.124.3.1105 Plant Physiol
10.1016/S0065-2776(03)81007-6 151 TremlJ.mejkalK
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