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GH and testosterone have well-documented additive effects on body composition testosterone drives muscle protein synthesis through androgen receptor activation, while GH promotes lipolysis, collagen synthesis, and tissue repair through separate pathways

ROS production can occur at several intracellular sites but, for most cells, takes place in the mitochondria and the mitochondrial electron transport chain is the main cellular process of ROS generation in physiological circumstances (14)

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The authors thank the support from the National Institutes of Health (AI182369, AI182177 and CA287076 to H.W

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