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For a compound to gain FDA approval, it must go through extensive, multi-phase clinical trials in humans to prove both safety and efficacy for a specific condition

Consider saliva stimulating options such as sugar free gum with xylitol

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That is clearly unacceptable and major pressure is needed to get all companies making this class of drugs to test and validate durable and safe exit strategies

Accordingly, future progress in this field will depend on integrating organoid engineering with immunology, vascular biology, and high-content analytical platforms (75, 76)