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Recent studies show that GLP-1(936) can activate the inhibitory G protein (Gi/o), leading to the translocation of secretory granules (SG) beneath the cell membrane, thereby inhibiting glucagon secretion

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(2) serum IGF-1 and IGFBP-3 levels as a baseline biomarker anchor

Van Opdenbosch N, Lamkanfi M

Curr Top Behav Neurosci 31:7394 Dong C, Zhang J, Yao W, Ren Q, Yang C, Ma M, Han M, Saito R, Hashimoto K (2016) Effects of escitalopram, R-citalopram, and reboxetine on serum levels of tumor necrosis factor-, interleukin-10, and depression-like behavior in mice after lipopolysaccharide administration

Plasma MDA (a lipid peroxidation marker) should decrease or remain stable despite ongoing weight loss if MDA rises while glutathione increases, oxidative stress exceeds antioxidant capacity and dosing adjustments are needed