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A phase III trial compared trastuzumab emtansine to treatment chosen by physician in patients with advanced HER2-positive breast cancer
This foundational understanding opens the door for novel interventions aimed at modulating the microbial community itself
These SCFAs bind to specific receptors on L-cells, notably the free fatty acid receptors FFAR2 and FFAR3, which directly stimulate GLP-1 secretion
Heart-rate changes are seen across the incretin class, but the glucagon component may contribute here, and the long-term clinical significance is precisely the kind of question phase 3 cardiovascular follow-up is meant to resolve
Trials on Zepbound found that 0.1% of patients had a severe hypersensitivity reaction (such as anaphylaxis) compared to 0% in the placebo group
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