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Studies suggest it may improve lipid profiles and reduce cardiovascular risk factors, which are often elevated in people with obesity or type 2 diabetes

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Current FDA guidance notes that semaglutide carries a theoretical black-box warning for personal or family history of medullary thyroid carcinomaa genuine contraindicationbut population-level cancer surveillance shows no increased incidence

According to clinical trial data, some people using semaglutide report muscle cramps, which may include leg cramps