Blood samples (100 L each) were collected from mice via cardiac puncture and allowed to clot at room temperature for 30 min
Use of GLP-1 receptor agonists such as Ozempic (semaglutide injection) and Wegovy (semaglutide injection) may be associated with gastrointestinal (GI) side effects including flatulence and abdominal pain
Retatrutide remains investigational and is not FDA-approved, so patients should only consider it within legitimate clinical trial settings
03Pair with training and dietFor best results, keep up a routine of exercise, hydration and a balanced diet
GLP-1 receptor agonists enhance glucose-dependent insulin secretion from pancreatic beta cells, meaning they stimulate insulin release only when blood glucose levels are elevated
Newer data, including the 2025 SEMALEAN study, shows that lean mass can be largely preserved when adequate protein, resistance training, and body composition monitoring are built into the protocol