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NAD+ deficiency could indicate muscle loss, oxidative stress, and the start of many life-limiting diseases

Thats how it was discovered that levels were getting intracellularly and increasing

10.1073/pnas.150084897 56 NorrgrdM

Six years later, paracetamol was discovered in the urine of individuals who had taken phenacetin, and was concentrated into a white, crystalline compound with a bitter taste