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It is important to note that the FDA-approved clinical trials for semaglutide and tirzepatide studied the injectable formulations

GLP-1 receptor activation slows gastric emptying, increases satiety, and improves glucose-dependent insulin secretion

Peptide Codex

Upon binding to their respective receptors on pancreatic beta cells, GIP and GLP-1 enhance insulin secretion in a glucose-dependent manner

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This is typically reversible with dose reduction or discontinuation