Patients should also be informed about serious gastrointestinal adverse events that require urgent medical attention, including severe persistent abdominal pain (with or without vomiting) which may indicate pancreatitis, symptoms of gallbladder disease, or signs of dehydration
Additionally, the metabolic changes induced by improved glycemic control might influence peripheral nerve function or microvascular perfusion, though this has not been systematically studied in humans and data remain limited
The primary criterion for dose increase is inadequate achievement of individualized glycemic targets after a minimum of four weeks at the current dose
The National Institute for Health and Care Excellence (NICE) guidelines for diabetes and obesity management recommend individualised assessment when prescribing these medications, with NHS access to weight management formulations following specific NICE criteria (TA875)
Better health: Lose weight
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