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Diuretics (commonly prescribed for hypertension or heart failure) directly increase urine production

After a particularly unsatisfying trip to Sedona, AZ, where I didn't feel up to doing my usual hiking, I realized that I needed to do something

Front Neurosci 14:583097 King MR, Anderson NJ, Deciu M, Guernsey LS, Cundiff M, Hajizadeh S, Jolivalt CG (2020) Insulin deficiency, but not resistance, exaggerates cognitive deficits in transgenic mice expressing human amyloid and tau proteins

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For instance, in clinical trials with tirzepatide (marketed as Mounjaro or Zepbound), over half of the participants lost more than 20% of their body weight