The decreases in systolic and DBP were 1.05 mm Hg and -0.92 mm Hg, respectively, as expressed per kilogram of weight lost
However I think any medication should be very sparingly used and only if absolutely needed
However, its use beyond this approved indication, such as for erectile dysfunction in men, is considered off-label
Treatment-related AEs were defined as those assessed as definite, probable, or possible
The label goes further: tolerance to the appetite effect usually develops within a few weeks, and when that happens the instruction is to stop the medication, not increase the dose
Myofibroblasts are the primary producers of collagen in tissue fibrosis 67,68 and play a role in tissue stiffness and the development of skin and joint contractures in SSc patients