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Previous studies have shown that internalization of these receptors following ligand stimulation is more pronounced in IR than IGF1R (14), and this effect is decreased in insulin-resistant obese subjects and obese type 2 diabetic patients (24)

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GLP-1 patches don't contain any GLP-1, they haven't been clinically approved, and there's no strong evidence that they lead to meaningful weight loss

Medicaid coverage varies widely by state, with only 13 states including an anti-obesity drug in their formularies as of August 2024

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Try eating small, balanced meals regularly