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Aug 12 2021;10(8)doi:10.3390/cells10082067 Nightingale TE, Moore P, Harman J, et al

They help the pancreas release insulin when blood sugar is high, work by slowing stomach emptying, and reduce appetite and food intake-which together promote weight loss and improve blood sugar levels

PMID: 18025815

In this study, the difference in body weight reduction between tirzepatide- and semaglutide-treated groups can only partly explain the improvement in insulin sensitivity, lending support to the observation that tirzepatide was associated with improvements in insulin sensitivity associated with both body weight-lowering and a potential insulin-sensitizing effects of GIP

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