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Conclusion: The Evolving Landscape of Weight Loss Treatment The development of GLP-1 medications, dual GIP/GLP-1 agonists, and emerging triple-agonist medications represents one of the most significant advances in obesity medicine in decades

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Losing weight with medication support sets the stage for sustainable lifestyle changes and long-term weight management

However, both medications affect the gastrointestinal systemtirzepatide by slowing motility and orlistat by preventing fat absorptionwhich may compound digestive side effects when used together

Lancet (2019) 394:12130