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J Biol Chem 285(17):1307913091

Some preclinical studies have explored DSIP in pain pathway models, investigating its interaction with opioid receptor systems and examining behavioral pain measures in animal subjects under controlled research conditions

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In 58.8% (10/17) of patients, NIRS data were improved and ammonia levels were decreased, whereas 23.5% (4/17) of patients showed improved NIRS data without decreasing serum ammonia levels at 8 weeks