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In addition to summarising the current progress, this review also emphasises the emerging integration of medicinal chemistry and delivery science as the basis for the development of intelligent, safe and clinically convertible PROTAC therapies, so as to promote the evolution of precise protein degradation to a mature drug discovery paradigm
New England Journal of Medicine , 2015;373(1):11-22
A preliminary randomised controlled trial to compare the effects of duloxetine and acetyl-l-carnitine on pain, depression, anxiety, and well-being in patients with fibromyalgia suggested that acetyl-l-carnitine was efficacious in improving depressive symptoms, pain, and quality of life [91]
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