In eye diseases like DR, high blood glucose and oxidative stress activate the Notch1-Hes signaling pathway, leading to ECM imbalance and promoting vascular dysfunction, inflammation, and retinal damage ( 2.5 Anti-angiogenic effect Abnormal angiogenesis plays a significant role in the pathogenesis of several eye diseases, particularly those involving retinal ischemia and neovascularization
Severe Fatigue If the fatigue is severe and interferes with your daily activities, you should contact your healthcare provider immediately
GLP-1 receptor agonists cause bloating by slowing gastric emptying, which prolongs food transit through the digestive system and increases gas production
Safety First GLP-1 medications can cause side effects that impact airman safety: nausea, dizziness, fatigue, orrarelymood changes
This distinction is critical for determining the location of the bleeding within the GI tract
doi: 10.1371/journal.pone.0270899 100