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Manufacturers paid billions in settlements, and confidence in the category evaporated

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According to KFF surgery data, about 1 in 8 individuals in the United States has used GLP-1 medications during their life and currently, approximately 15 million adults (or 6% of the population) are using prescription drugs for weight loss, type 2 diabetes, or lowering the risk of cardiovascular diseases

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However, native GLP-1 has a limited half-life (1.55 min) due to its degradation by the enzyme Dipeptidyl peptidase 4 (DPP-4), necessitating the development of GLP-1 receptor agonists (GLP-1RAs) with longer activity (Campbell and Drucker 2013)