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Across pivotal trials, nausea occurred in 42% of participants on GLP-1 agonists, 45% on dual agonists, and 50% on triple agonists, with similar patterns for vomiting and diarrhea (Table 4 and Figure 2)
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And we are not fully clear on specific mechanisms, like the black box, or potential side effects and downsides, Dillon said
A substudy of this phase 1b trial showed also that retatrutide delays gastric emptying in humans, as measured by the acetaminophen test, though this effect lessens over time due to tachyphylaxis [44]
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