Mechanisms of drug resistance include epithelial-mesenchymal transition, DNA repair activation, reduced drug uptake, enhanced drug efflux, changes in pro-apoptotic and anti-apoptotic genes, changes in tumor cell microenvironment, and redox imbalance
interestingly two in silico screenings independently identified the COX-II inhibitor celecoxib as a potential anti-SARS-CoV-2 drug, and a very recent study still under peer review reports its beneficial effects plus famotidine in hospitalized patients (Tomera et al., 2020)
Last year, the lab of Vadim Gladyshev, another Harvard biologist and a member of a different XPrize team, reported on its attempt to rejuvenate mice by installing pumps in their bodies that released controlled doses of seven compounds
doi:10.1080/13813450701661198
A form of skincare superstar, Vitamin C
Type III PRMTs are currently the only known PRMT7, which produces only monomethylarginine