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Examples include Tryptyr (acoltremon) , a first-in-class TRPM8 thermoreceptor agonist indicated for the treatment of the signs and symptoms of dry eye disease, and BRINSUPRI (brensocatib) , a first-in-class oral DPP1 inhibitor for non-cystic fibrosis bronchiectasis (NCFB), offering new treatment options for diseases that previously lacked effective therapies

This association has led researchers to explore whether the metabolic dysfunction underlying diabetesincluding insulin resistance, chronic inflammation, and vascular damagemight also contribute to neurodegeneration

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Neither is an FDA-approved drug for human therapeutic indications