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Astragaloside IV can inhibit the phosphorylation of the mTOR signaling pathway, downregulate the Bcl-6 transcription factor in Tfh, and upregulate the CTLA-4 expression in T follicular regulatory cells (Tfr), thereby reshaping the Tfh/Tfr balance to reduce the release of pro-inflammatory factors such as IL-21

However, the study lacked a placebo control, limiting interpretation (Kalamkar et al., Antioxidants, 2022) [55]

In addition to supplements, you can support your body's natural production of healthy glutathione levels by putting sulfur-rich foods like spinach, avocados, asparagus, and broccoli on the menu

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