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NRF2 pathway and ferroptosis in the testis Nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor that regulates antioxidant reactions, and its antioxidant effects lie in its ability to induce the expression of downstream antioxidant genes
It protects the cancerous cells by conferring resistance to chemotherapeutic drugs
They are particularly beneficial for older adults and those with conditions that impair B12 absorption
Conversely, the increased SOD activity in the cerebellum of the VPA group suggests compensatory antioxidant responses in specific regions
In silico molecular docking further supports this, showing that Epitalon has a high binding affinity for specific histone subtypes, H1/3 and H1/6, which play a regulatory role in chromatin compaction and accessibility [4]
Exfoliate Regularly: Use gentle chemical exfoliants (like AHAs or BHAs) or natural scrubs to remove dead cells
