Until such evidence is available for retatrutide, therapies with established cardiovascular and renal benefitssuch as semaglutide, supported by SUSTAIN-6 [5] and FLOW [57] trials in people with T2D, and the SELECT trial [58] in people with obesity - should be prioritised in populations with existing cardio-renal disease

Key sources included the US Food & Drug Administration (FDA), European Medicines Agency (EMA), Pharmaceuticals and Medical Devices Agency (PMDA) Japan, Medicines and Healthcare products Regulatory Agency (MHRA) UK, National Institutes of Health (NIH), National Center for Biotechnology Information (NCBI/PubMed), Centers for Disease Control and Prevention (CDC) National Diabetes Statistics Report, World Health Organization (WHO) Global Health Observatory, International Diabetes Federation (IDF) Diabetes Atlas, American Diabetes Association (ADA) Standards of Care, European Association for the Study of Diabetes (EASD) Guidelines, IQVIA Institute for Human Data Science, Evaluate Pharma, and national health ministry reports from key markets (China NMPA, India CDSCO, Brazil ANVISA)
Although Canada does not allow the kind and level of direct-to-consumer advertising for prescription drugs, an opinion piece in Campaign in Canada, the marketing and ad industry publication thats a sister to a U.S
They are also contraindicated in individuals with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia type 2, based on preclinical findings in rodent models
173-88, Ronkainen PHA, Kovanen V, Aln M, et al
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