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During the in vivo investigation on AR mice, it has been confirmed that treatment with (2 S , 7 S )- O -(2-methyl butanol)-columbianetin reduced the histamine, IgE, and IL-1 levels in serum also reduced the MIP-2 and Intercellular Adhesion Molecule 1 (ICAM-1) protein levels and eosinophils and mast cells in the nasal mucosa tissue and reduced the spleen weight and increased the IFN- levels in the spleen tissue (Nam et al., 2014)

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