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The trials size, the fact that it was open-label, single-arm, not peer-reviewed or even published, and commissioned by the company

Additionally, concomitant use with other GLP-1 receptor agonists is not recommended

"They also act on your brain as well, where it controls your appetite, sexual function and a lot of things to do with your emotional decision making

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In a 2017 review, Kruglikov et al

This leads to a long list of negative effects, such as: tears and scarring, weak spots that rupture easily, blood clots, increased plaque buildup, and increased workload on the heart