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2.1.2 Excessive production of mtROS Mitochondrial complexes are the main producers of mtROS (Yin et al., 2021), and the excessive production of mtROS and inhibition of antioxidase cause an imbalance in redox reactions (Springo et al., 2015), which promotes mtDNA mutations (Fontana and Gahlon, 2020), aggravates NF-B activation (Csiszar et al., 2014), excites NAD(P)H oxidase (NOX) in the cytoplasm (Canugovi et al., 2019), and develops vascular oxidative stress and inflammation

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The long-term cardiovascular safety and efficacy of glucagon-like peptide-1 (GLP-1) receptor agonists in high-risk cardiovascular populations: a systematic review and meta-analysis