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Wegovy (semaglutide) and Zepbound (tirzepatide) work by mimicking hormones that signal fullness to your brain and slow how quickly food leaves your stomach. This dual effect eliminates the usual hunger signals you're accustomed to feeling

In addition to helping the body release more insulin, semaglutide slows down how quickly the stomach empties food into the intestines

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Compounding effects Excessive inventory levels and declining demand, coupled with persistent inflation and high interest rates, placed severe pressure on the Company's margins, cash flows, and liquidity

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For patients whose disease progresses on these regimens, alternative regimens or second-line options, such as liposomal irinotecan combined with 5-FU, may be considered if not previously administered [24]