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It is possible that the significant decrease of serum IL-5 in ALS patients at the first visit shown in our current study indicated suppression of B cell activation and/or antibody production, likely due to the existing large amount of IgG in sera

We further show that the binding of GTP to the NADH-bound GDH activates a triangular allosteric network, interlinking the inhibitor with regulatory and catalytic sites

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Pediatr Neonatol 2020;61:620-8