Adverse Reactions/Side Effects Reactions which may occur because of this solution, added drugs or the technique of reconstitution or administration include febrile response, local tenderness, abscess, tissue necrosis or infection at the site of injection, venous thrombosis or phlebitis extending from the site of injection and extravasation
Extended-release tablets release the vitamin slower, which might help it stay in the body longer
Clinical signs of B12 deficiency include nausea, vomiting, loss of appetite, poor absorption of food (malabsorption syndrome), constipation, gas, weight loss, fatigue, lethargy, abdominal pain, and diarrhea
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but I would take that to mean that once you are on an adequate amount of B12 injections and no longer have large red blood cells , both folate and ferritin should remain at a good level with a healthy diet
If you experience fatigue or paradoxical symptoms like headaches, it's likely a detoxification reaction