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They can affect the survival, proliferation, metastasis, recurrence, drug resistance, and other functions of tumor cells through altering the function, activity, subcellular localization, protein-protein interactions, protein stability, other modification levels of non-histone proteins, and modifying histones to change gene expression, chromatin accessibility, transcriptional activity, all of which are closely related to the initiation and progression of tumors
Combined with the theory of GIP being an obesogenic hormone (53), these prior findings have highlighted the potential of GIP receptor antagonism, and today the development of GIP receptor antagonists has also emerged as an attractive therapeutic approach for addressing obesity and cardiovascular diseases (54, 55)
Christiansen L, Beck MM, Bilenberg N, Wienecke J, Astrup A, Lundbye-Jensen J
Sci Rep 7:2749
10.1002/oby.22090 17 CrosthwaitJ.SyeddanS.AtlasE
The tool did not influence the study design, data collection, analysis, interpretation, or the scientific content of the work
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