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The FDA early this year removed that black box warning after a comprehensive analysis of many thousands of patients who have taken this medication, and across that huge cohort, there has been no increased risk of depression or suicidality. What further research still needs to be done about GLP-1 medications and alcohol use

doi: 10.1016/j.regpep.2004.06.020 50 MentleinRGallwitzBSchmidtWE

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Meanwhile, the subsequent introduction of antioxidant agents like lipoic acid led to the alleviation of these conditions [6, 41, 42]