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This contraindication applies to semaglutide (Ozempic, Wegovy, Rybelsus), dulaglutide (Trulicity), liraglutide (Victoza, Saxenda), exenatide extended-release (Bydureon BCise), tirzepatide (Mounjaro, Zepbound), and the combination product Xultophy (insulin degludec/liraglutide)
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Two huge reasons: Extended Half-Life: Standard IGF-1 has a half-life of only about 10-20 minutes
Growth hormone-releasing peptide-6 stimulates sleep, growth hormone, ACTH and cortisol release in normal man
Amino acids L-Alanine (AAA1580414), L-Cystine (AAA1376218), L-Glutamine (AAA1420118), L-Histidine (AAA1762718), L-Methionine (AAA1031822), L-Phenylalanine (AAA1323814), L-Proline (AAA1019914), L-Serine (AC132660250) and L-Tyrosine (AAA1114118) were obtained from Thermo Fisher
Voltage-gated sodium channels were blocked by 0.5 M tetrodotoxin (TTX) (Tocris)
