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The oral route of administration pose challenges due to the drugs high molecular weight, extremely low absorption with the commercially available oral tablets and the drugs sensitivity to the heat required to compound it into a lozenge

doi: 10.1089/ars.2007.1957 281 TrapaniV.RosanoffA.BaniasadiS.BarbagalloM.CastiglioniS.Guerrero-RomeroF.et al

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Renal and hepatic function are important considerations, as impaired organ function can affect drug metabolism and clearance

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