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For quality control, we excluded participants who (1) have excess relatedness (more than 10 putative third-degree relatives), (2) have inconsistent information about sex based on genotyping and self-report, (3) have sex-chromosomes not XX or XY, (4) have poor-quality genotyping based on heterozygosity and missing rates, or (5) have withdrawn from UK Biobank

To further delineate pathways that are responsive to GSTO1 knockdown, we performed gene set enrichment analysis (GSEA) using the Bru-seq data (Supplementary Tables 12 and 13)

For example, semaglutide for diabetes (Ozempic) typically starts at 0.25 mg weekly for four weeks, then increases to 0.5 mg weekly

Additionally, the included Zinc helps maintain normal testosterone levels in the blood

The ghrelin receptor stimulates the secretion (but not synthesis) of stored growth hormone