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The SURPASS-CVOT trial showed approximately 12% weight loss with tirzepatide compared with 5% with dulaglutide, along with nearly double the HbA1c reduction
A large-scale clinical trial (1019 patients) failed to demonstrate significant efficacy, attributed to a robust placebo effect, insufficient dosing or formulation changes [147]
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A small number of cancers (basal cell carcinoma, breast cancer, malignant melanoma, lipoma, squamous cell carcinoma) were reported during the 12-week oral METAOD005 trial
Invest 79 , 616619 (1987)
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