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A structurally conserved site in AUP1 binds the E2 enzyme UBE2G2 and is essential for ER-associated degradation
Concurrently, ROS oxidatively modify tau protein, enhancing its hyperphosphorylation and subsequent aggregation into neurofibrillary tangles, thereby disrupting microtubule stability and axonal transport [334]
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Trkb Penk -KO mutants exhibited a significant increase in TH + cells in the SNcVTA regions after 1 month of GSTO2 upregulation
Low levels of vitamin B12 (vitamin B12 deficiency)
Each receptor limb contributes a distinct downstream effect in preclinical models, and their concurrent activation is hypothesised to produce additive or synergistic metabolic signalling
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