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In a retrospective clinical study, patients with severe aortic stenosis had higher serum levels of TMAO compared to control subjects, even after adjusting for baseline characteristics 32

Therapeutic-Model Protocol Dose: 0.50 1.00 mg (= 2040 clicks) Duration: 6 8 weeks Frequency: Daily Cycle Interval: 2 3 weeks off between cycles Goal / Description: Higher dose to assess enhanced lipolysis and energy utilization

Definitions of all these variables using administrative claims are described in Additional file 1: Table S1

While these findings have not been linked to serious adverse outcomes so far, they highlight the need for long-term safety studies, which are currently underway in Phase 3 trials

It is best to discard the vial and contact your provider for a replacement