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[6] SAM may act as a methyl donor in the metabolic processes that control lipid homeostasis, DNA stability, gene expression, and neurotransmitter release, which may account for the benefits it confers
Scientific References Hydroxocobalamin Drugs BNF
When neurological symptoms are present, more intensive treatment is required: 1 mg hydroxocobalamin on alternate days until no further improvement occurs, followed by maintenance therapy every two months
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Because its a peptide, it must be injected (or taken orally in specific cases) to preserve its structure and ensure it reaches target tissues