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Moreover, 61.8% of participants on semaglutide lost 10% of baseline weight, and over a third of participants had achieved at least 20% weight loss at week 104 in the semaglutide group

That includes signals tied to swelling, oxidative stress, and tissue breakdown

J., & Gianello, R

Higher baseline weights typically produce larger absolute losses

However, stomach acid is needed to break B12 from food so that it can be absorbed and so these medications can lead to reduced absorption and ultimately deficiency

As with any therapy, long-term studies are still limited, so ongoing observation and clinical research will further define its safety profile